Sounds like a prolific acronym and for those who are told they have issues with MTHFR, they probably feel like using those 5 letters it in the same vein. MTHFR stands for methylene-tetrahydrofolate reductase. Basically MTHFR is an enzyme that converts the folate that you eat into the active form (5-Methyltetrahydrofolate). The folate that we eat needs to be converted by a relatively complex sequence of steps to become the active folate 5-MTHFR. It’s important to understand that the MTHFR enzyme affects the last step in the sequence and for those with a mutation in the gene, it will affect how much active folate is readily available for your body to utilise.